2-(Quinolin-2-YL)acetic acid → HCID 67930077, compound

HRID 35003Notes

Reaction equation

HRID 35003 reaction equation
[NH2:1][CH:2]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH3:17])[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1.[N:18]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:25]=[CH:24][C:19]=1[CH2:20][C:21](O)=[O:22]>>[CH3:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[CH:2]([NH:1][C:21]([CH2:20][C:19]1[CH:24]=[CH:25][C:26]2[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:18]=1)=[O:22])[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 47117842-(Quinolin-2-YL)acetic acidHCID 212976891-[3-Amino-3-(2-methylphenyl)propyl]piperidine

Product 1

HCID 67930077HCID 67930077, compoundYield 95%

Procedure

The procedure of Example 4 was repeated using 465 mg (2.0 mmol.) of 1-[3-amino-3-(2-methylphenyl)propyl]piperidine and 347 mg (2.0 mmol.) of quinaldinic acid, to obtain 736 mg (yield: 95%) of the subject compound as a pale yellow oily product.

Sources & evidence

ORD record
ord-8f4f86a139b14d1e982c61142019ca96
Source dataset
uspto-grants-1988_08
Patent number
US04764617

Reaction notes

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