1-[3-Amino-3-(3-methylphenyl)propyl]piperidine → N-[1-(3-methylphenyl)-3-piperidinopropyl]quinaldinamide

HRID 35005Notes

Reaction equation

HRID 35005 reaction equation
[NH2:1][CH:2]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[CH:12]=1)[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1.[N:18]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:25]=[CH:24][C:19]=1[CH2:20][C:21](Cl)=[O:22]>>[CH3:17][C:13]1[CH:12]=[C:11]([CH:2]([NH:1][C:21]([CH2:20][C:19]2[CH:24]=[CH:25][C:26]3[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=3)[N:18]=2)=[O:22])[CH2:3][CH2:4][N:5]2[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]2)[CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 137991191-[3-Amino-3-(3-methylphenyl)propyl]piperidineHCID 86742336Quinaldinoyl chloride

Product 1

HCID 67930045N-[1-(3-methylphenyl)-3-piperidinopropyl]quinaldinamideYield 65%

Procedure

The procedure of Example 1 was repeated using 697 mg (3.0 mmol.) of 1-[3-amino-3-(3-methylphenyl)propyl]piperidine and 575 mg (3.0 mmol.) of quinaldinoyl chloride, to obtain 755 mg (yield: 65%) of the subject compound as a pale yellow solid product.

Sources & evidence

ORD record
ord-e77a6a192f674bfc81943b3df6788c18
Source dataset
uspto-grants-1988_08
Patent number
US04764617

Reaction notes

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