Fumaric Acid → N-[1-(3-methylphenyl)-3-piperidinopropyl]quinaldinamide fumarate

HRID 35006Notes

Reaction equation

HRID 35006 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]([NH:17][C:18]([CH2:20][C:21]2[CH:30]=[CH:29][C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[N:22]=2)=[O:19])[CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:5]=[CH:6][CH:7]=1.[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35]>>[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35].[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]([NH:17][C:18]([CH2:20][C:21]2[CH:30]=[CH:29][C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[N:22]=2)=[O:19])[CH2:9][CH2:10][N:11]2[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 444972Fumaric AcidHCID 67930045N-[1-(3-methylphenyl)-3-piperidinopropyl]quinaldinamide

Product 1

HCID 86742339N-[1-(3-methylphenyl)-3-piperidinopropyl]quinaldinamide fumarateYield 70%

Procedure

The procedure of Example 11 was repeated using 678 mg (1.75 mmol.) of N-[1-(3-methylphenyl)-3-piperidinopropyl]quinaldinamide and 203 mg (1.75 mmol.) of fumaric acid, to obtain 620 mg (yield: 70%) of the subject compound as a white crystalline product.

Sources & evidence

ORD record
ord-c2af81cda682437b9c704fa844f66916
Source dataset
uspto-grants-1988_08
Patent number
US04764617

Reaction notes

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