1-[3-Amino-3-(4-methoxyphenyl)propyl]piperidine → N-[1-(4-methoxyphenyl)-3-piperidinopropyl]quinaldinamide

HRID 35009Notes

Reaction equation

HRID 35009 reaction equation
[NH2:1][CH:2]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1)[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1.[N:19]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH:26]=[CH:25][C:20]=1[CH2:21][C:22](Cl)=[O:23]>>[CH3:18][O:17][C:14]1[CH:13]=[CH:12][C:11]([CH:2]([NH:1][C:22]([CH2:21][C:20]2[CH:25]=[CH:26][C:27]3[C:32](=[CH:31][CH:30]=[CH:29][CH:28]=3)[N:19]=2)=[O:23])[CH2:3][CH2:4][N:5]2[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10]2)=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 212976871-[3-Amino-3-(4-methoxyphenyl)propyl]piperidineHCID 86742336Quinaldinoyl chloride

Product 1

HCID 67930051N-[1-(4-methoxyphenyl)-3-piperidinopropyl]quinaldinamideYield 85%

Procedure

The procedure of Example 1 was repeated using 745 mg (3.0 mmol.) of 1-[3-amino-3-(4-methoxyphenyl)propyl]piperidine and 575 mg (3.0 mmol.) of quinaldinoyl chloride, to obtain 1.03 g (yield: 85%) of the subject compound as a pale yellow oily product.

Sources & evidence

ORD record
ord-9a135f5e01024091b2def570c7e98ab6
Source dataset
uspto-grants-1988_08
Patent number
US04764617

Reaction notes

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