Triethyl phosphonoacetate → HCID 69422740, compound

Participants

Reaction Steps

To a mixture of 1-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyl]-3-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxy]-1H-pyrazol-4-carbaldehyde (25.20 g), ethyl diethylphosphonoacetate (9.50 g), and N,N-dimethylformamide (200 ml), sodium hydride (60%, oily, 1.68 g) was added at 0° C., and the mixture was stirred at room temperature for 2 hours. The reaction mixture was added to ice water, and the obtained crystals were collected by filtration, and ethyl(E)-3-[1-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyl]-3-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxy]-1H-pyrazol-4-yl]propenoate (25.58 g, yield: 92%) was obtained. This was recrystallized from tetrahydrofuran-hexane. Melting point: 148–149° C.

Provenance & Evidence