Triethyl phosphonoacetate → HCID 69420190, compound

Participants

Reaction Steps

To a mixture of 1-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]benzyl]-3-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]benzyloxy]-1H-pyrazol-4-carbaldehyde (14.09 g), ethyl diethylphosphonoacetate (5.88 g), and N,N-dimethylformamide (100 ml), sodium hydride (60%, oily, 1.01 g) was added at 0° C., and the mixture was stirred at room temperature for two hours. The reaction mixture was poured into ice water, and the obtained crystals were collected by filtration, and ethyl(E)-3-[1-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]benzyl]-3-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]benzyloxy]-1H-pyrazol-4-yl]propenoate was obtained (13.91 g, yield: 89%). This was recrystallized from ethyl acetate-hexane. Melting point: 138–139° C.

Provenance & Evidence