HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → Methyl 3-(piperidin-1-ylmethyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Methyl 3-(bromomethyl)benzoate | HCID 517981 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Methyl 3-(piperidin-1-ylmethyl)benzoate | HCID 7162043 | — |
Reaction Steps
A mixture of piperidine (25 ml) and 3-(bromomethyl)benzoic acid, methyl ester (20 g) in toluene (600 ml) was stirred at room temperature for 4 h. The white preciptiate was removed by filtration and the filtrate was distilled to give the title compound as a colourless oil (17.56 g) b.p. 110° (10-1 mm). TLC silica; ether; Rf 0.7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04764612 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-d2db7d61cdb94d9a851edbff15c6518d |
| Source note | uspto-grants-1988_08 |