Methyl 3-(piperidin-1-ylmethyl)benzoate → (3-((Piperidin-1-yl)methyl)phenyl)methanol

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Reaction Steps

A mixture of 3-(1-piperidinylmethyl)benzoic acid, methyl ester (17.56 g) and lithium aluminium hydride (2.58 g) in tetrahydrofuran (500 ml) was stirred at room temperature for 30 h and quenched with water. The solid was removed by filtration and the filtrate distilled to give the title compound as a colourless oil (11.1 g) b.p. 135° (10-1 mm). TLC silica; ether; Rf 0.2.

Provenance & Evidence