HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 4-[3-Aminopropoxy]-N,N-dimethylbenzeneethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-[3-[4-[2-(Dimethylamino)ethyl]phenoxy]propyl]-1H-isoindole-1,3-(2H)-dione | HCID 21297567 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-[3-Aminopropoxy]-N,N-dimethylbenzeneethanamine | HCID 21297555 | — |
Reaction Steps
2-[3-[4-[2-(Dimethylamino)ethyl]phenoxy]propyl]-1H-isoindole-1,3-(2H)-dione (2.1 g) and hydrazine hydrate (1.2 ml) were heated at reflux in ethanol for 4 h. The solvent was evaporated and the residue was distilled to give the title compound as a clear yellow oil b.p. 170° (0.1 mm). TLC silica; ethyl acetate:water:isopropanol:0.88 ammonia 25:8:15:2; Rf 0.35.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04764612 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-e9691496ea77480eb79e86d3492a6098 |
| Source note | uspto-grants-1988_08 |