反应详情

温度

20 °C

A mixture of 1.40 g of the product from stage 1 and 3.40 g of pyridinium dichromate in 350 ml of anhydrous dichloromethane was stirred for 24 hours at 20° C. The solution was then filtered and the filtrate was concentrated by evaporation in vacuo. The residue was purified by flash chromatography on silica gel with ethyl acetate/cyclohexane (1/1) as eluent, 0.88 g (64% of theory) of the title compound being obtained in crystalline form.

1. filtrationThe solution was then filtered
2. concentrationthe filtrate was concentrated by evaporation in vacuo
3. customThe residue was purified by flash chromatography on silica gel with ethyl acetate/cyclohexane (1/1) as eluent