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Benzyl Alcohol → 4-Benzyloxy-2-(trifluoromethyl)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Alcohol | HCID 244 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4-Fluoro-2-(trifluoromethyl)benzoic acid | HCID 688255 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Benzyloxy-2-(trifluoromethyl)benzoic acid | HCID 19013918 | — |
反応手順
A 5.2 g portion of 60% sodium hydride oil dispersion was suspended in 50 ml of DMF, and 6.73 ml of benzyl alcohol was added thereto under ice-cooling. After warming up to room temperature, 12.3 g of 4-fluoro-2-trifluoromethylbenzoic acid was added thereto and stirred at room temperature for 6 hours. A 1 M hydrochloric acid aqueous solution was added to the reaction mixture, and the thus precipitated crystals were collected by filtration to obtain 16.39 g of 4-(benzyloxy)-2-(trifluoromethyl)benzoic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07183271B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-d569174154e64f60a78bf22b698acdc1 |
| 出典メモ | uspto-grants-2007_02 |