HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → Lamtidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 1-Methyl-N5-[3-[3-(bromomethyl)phenoxy]propyl]-1H-1,2,4-triazole-3,5-diamine, hydrobromide | HCID 131712688 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Lamtidine | HCID 71988 | 89.7% |
Reaction Steps
1-Methyl-N5 -[3-[3-(bromomethyl)phenoxy]propyl]-1H-1,2,4-triazole-3,5-diamine, hydrobromide (0.3 g) was dissolved in ethanol (5 ml) and treated with piperidine (0.3 g) at room temperature. The solvent was evaporated in vacuo and the residue triturated with ethyl acetate to afford the title compound as a white crystalline solid (0.22 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04764612 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-3026301cb85c4bf49979e9d71d72d293 |
| Source note | uspto-grants-1988_08 |