Potassium Iodide → HCID 21973236, compound

Participants

Reaction Steps

3.67 g (16.4 millimoles) of 5-(2-chloroethylamino)-2-methyl-2H-pyridazine-3-one-hydrochloride, 90 ml of acetonitrile, 4.05 g (18.4 millimoles) of 6-fluoro-3-piperidine-4-yl-1,2-benzisoxazole, 6.84 g of potassium carbonate and 0.37 g of potassium iodide are admixed. The reaction mixture is stirred under heating to boiling for 24 hours, cooled to room temperature and filtered. To the product 100 ml of water are added and the aqueous phase is extracted five times with 50.0 ml of dichloro methane each. The united organic phases are washed with water, dried over anhydrous magnesium sulfate, filtered and the organic phase is evaporated in vacuo. The residue is suspended in diethyl ether and filtered. The crude product is recrystallized from acetonitrile. Thus 3.4 g of the desired compound are obtained. Yield 55.9%.

Provenance & Evidence