Potassium Iodide → HCID 21973227, compound

Participants

Reaction Steps

4.12 g (17.3 millimoles) of 5-(3-chloropropylamino)-2-methyl-2H-pyridazine-3-one-hydrochloride, 100 ml of acetonitrile, 4.29 g (19.5 millimoles) of 6-fluoro-3-piperidine-4-yl-1,2-benzisoxazole, 7.24 g of potassium carbonate and 0.39 g of potassium iodide are admixed. The reaction mixture is heated to boiling under stirring for 24 hours, cooled to room temperature and filtered. To the product 100 ml of water are added and the aqueous phase is extracted five times with 90 ml of dichloro methane each. The united organic phases are washed with a saturated sodium chloride solution; dried over magnesium sulfate and filtered over activated charcoal. The organic filtrate is evaporated in vacuo. The residue is suspended in diethyl ether and filtered. The crude product is recrystallized from acetonitrile. Thus 4.14 g of the desired compound are obtained. Yield 62.2%. M.p.: 163–165° C.

Provenance & Evidence