Hydrochloric Acid → HCID 69353272, compound

Participants

Reaction Steps

A mixture of ethyl(2E)-3-[2-(1H-benzimidazol-1-yl)-4-isopropyl-5-thiazolyl]propenoate (1.00 g), 2N aqueous sodium hydroxide solution (5 mL), tetrahydrofuran (5 mL), ethanol (5 mL) was stirred at room temperature for 1 hr. The reaction mixture was poured into dilute hydrochloric acid and the precipitated solid was collected by filtration, washed with water and dried to give (2E)-3-[2-(1H-benzimidazol-1-yl)-4-isopropyl-5-thiazolyl]propenoic acid (0.90 g, 98%) as crystals. Recrystallization from acetone-hexane gave pale-yellow prism crystals. melting point: 262–264° C.

Provenance & Evidence