HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 23061948, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 1-(3-Chlorophenyl)-2-hydroxyethan-1-one | HCID 13365907 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 23061948 | HCID 23061948 | 41% |
Reaction Steps
To a mixed solution of 1-(3-chlorophenyl)-2-hydroxyethanone (21.8 g), potassium cyanide (20.8 g) and 2-propanol (100 mL) was added acetic acid (18 mL) at room temperature. After stirring for 30 min, water was added, and the precipitated crystals were collected by filtration and recrystallized from methanol-diisopropyl ether to give 4-(3-chlorophenyl)oxazol-2(3H)-one (6.7 g, yield 41%) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07183276B2 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-a9e8cc26de6e4b78b32beb6c7e737c38 |
| Source note | uspto-grants-2007_02 |