Hydrochloric Acid → 3-{4-(4-chlorophenyl)-2-[2-(methylsulfonyl)-1H-imidazol-1-yl]-5-oxazolyl}propionic acid

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Reaction Steps

To a solution of methyl 3-{4-(4-chlorophenyl)-2-[2-(methylsulfonyl)-1H-imidazol-1-yl]-5-oxazolyl}propionate (1.4 g) in 1,4-dioxane (7 mL) was added 2N aqueous sodium hydroxide solution (3.5 mL) and the mixture was stirred at room temperature for 30 min. The reaction mixture was diluted with water, and acidified with 2N aqueous hydrochloric acid solution. The precipitated crystals were collected by filtration and recrystallized from methanol to give 3-{4-(4-chlorophenyl)-2-[2-(methylsulfonyl)-1H-imidazol-1-yl]-5-oxazolyl}propionic acid (1.22 g, yield 90%) as colorless prism crystals. melting point: 166–167° C.

Provenance & Evidence