Water → [2-Methyl-4-(5,6,7,8-tetrahydronaphthalen-2-yl)-5-oxazolyl]methanol

Participants

Reaction Steps

To a solution of methyl [2-methyl-4-(5,6,7,8-tetrahydronaphthalen-2-yl)-5-oxazolyl]carboxylate (4.5 g) in diethyl ether (90 mL) was added lithium aluminum hydride (0.63 g) at 0° C. After stirring the reaction mixture at room temperature for 30 min, water (3.2 mL) was added, and the precipitated solid was removed by filtration. The filtrate was concentrated and the obtained solid was washed with isopropyl ether to give [2-methyl-4-(5,6,7,8-tetrahydronaphthalen-2-yl)-5-oxazolyl]methanol (3.63 g, yield 90%) as crystals. Recrystallization from ethanol gave colorless crystals. melting point: 132–133° C.

Provenance & Evidence