Dimethylformamide → HCID 87796335, compound

Participants

Reaction Steps

A mixture of 3-[2-amino-4-(4-chlorophenyl)-5-thiazolyl]-N-[4-(diethylphosphonomethyl)phenyl]propionamide (500 mg), N,N-dimethylformamidedimethylacetal (155 mg) and N,N-dimethylformamide (10 ml) was stirred at room temperature for 1 hr. The reaction mixture was poured into water, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried over anhydrous magnesium sulfate, and concentrated. The residue was purified by silica gel column chromatography and 3-(4-(4-chlorophenyl)-2-{(E)-[(dimethylamino)methylidene]amino}-5-thiazolyl)-N-[4-(diethylphosphonomethyl)phenyl]propionamide was obtained as crystals (510 mg, yield: 92%) from a fraction eluted with 5% methanol-ethyl acetate. Recrystallization from ethyl acetate gave colorless prism crystals. melting point: 150–151° C.

Provenance & Evidence