tert-Butyl isocyanate → HCID 86597661, compound

Participants

Reaction Steps

A mixture of 3-[2-amino-4-(4-chlorophenyl)-5-thiazolyl)-N-[4-(diethylphosphonomethyl)phenyl]propionamide (400 mg), tert-butyl isocyanate (780 mg) and toluene (10 ml) was stirred at 70–80° C. for 20 hrs. The reaction mixture was concentrated. The residue was purified by silica gel column chromatography and 3-(4-(4-chlorophenyl)-2-([(tert-butylamino)carbonyl]amino}-5-thiazolyl)-N-[4-(diethylphosphonomethyl)phenyl]propionamide was obtained as crystals (395 mg, yield: 83%) from a fraction eluted with 3% methanol-ethyl acetate. Recrystallization from ethyl acetate gave colorless prism crystals. melting point: 180–181° C.

Provenance & Evidence