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3-Benzyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione → 1-(4-Aminophenyl)-3-benzyl-3-azabicyclo[3.1.1]heptane-2,4-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Benzyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione | HCID 14872633 | — |
| 反応物 | Diethylether ethylacetate | HCID 21584169 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 1-(4-Aminophenyl)-3-benzyl-3-azabicyclo[3.1.1]heptane-2,4-dione | HCID 14872638 | — |
反応手順
In a manner analogous to that described in Example 1a, 2.46 g of 3-benzyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione are dissolved in 50 ml of ethyl acetate, hydrogenated in the presence of 0.3 g of 5% palladium-on-carbon and worked up. Melting point 164°-165.5° (from ether/ethyl acetate).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04764640 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-c9d1fe1a90394c208267d55bc38fcf9f |
| 出典メモ | uspto-grants-1988_08 |