HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Isobutyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione → 1-(4-aminophenyl)-3-isobutyl-3-azabicYclo[3.1.1]heptane-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Isobutyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione | HCID 14872630 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(4-aminophenyl)-3-isobutyl-3-azabicYclo[3.1.1]heptane-2,4-dione | HCID 14872635 | — |
Reaction Steps
In a manner analogous to that described in Example 1, 2.0 g of 3-isobutyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione in 100 ml of ethanol are hydrogenated in the presence of 0.1 g of palladium-on-carbon and worked up. Melting point 158°-160° (from ethyl acetate/petroleum ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04764640 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-a373dd724e3f4a1699ee9e794b6b26ab |
| Source note | uspto-grants-1988_08 |