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Potassium Carbonate → 4-((Isopropyl(methyl)amino)methyl)thiazol-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Thiazolamine, 4-(chloromethyl)-, hydrochloride (1:1) | HCID 73228 | — |
| 反応物 | N-Methylisopropylamine | HCID 78485 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-((Isopropyl(methyl)amino)methyl)thiazol-2-amine | HCID 21090604 | — |
反応手順
N-methyl-N-isopropylamine (3.02 g, 41 mmol) is added to a suspension of 2-amino-4-chloromethylthiazole hydrochloride (0.185 g, 1.0 mmol) in 15 mL ethanol. The reaction mixture is allowed to stand at room temperature for 4 days. The mixture was poured into aqueous potassium carbonate. The resulting aqueous suspension is extracted with dichloromethane. The organic layer is dried over MgSO4 and condensed to brown oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07183300B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-c3743e0ec4dd42899e707ab5c78cd1e5 |
| 出典メモ | uspto-grants-2007_02 |