HRID350982

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID605123

2-(4-Fluorophenoxy)nicotinic acid

C12H8FNO3

HCID2736879

2-[(2H-1,3-Benzodioxol-5-yl)oxy]pyridine-3-carboxylic acid

C13H9NO5

HCID18174008

未命名化合物

HCID23529364

未命名化合物

PRODUCTS

生成物

结构：CC(Oc1ccc(CNC(=O)c2cccnc2Oc2ccc(F)cc2)c(F)c1)C(=O)OC(C)(C)C

HCID23529358

未命名化合物

PROCEDURE

实验过程

The compound of Formula (5.0.24) was prepared in a manner analogous to that described in Preparation 20, substituting 2-(4-fluoro-phenoxy)-nicotinic acid and (±)-2-(4-aminomethyl-3-fluoro-phenoxy)-propionic acid tert-butyl ester for the corresponding 2-(benzo-[1,3]-dioxol-5-yloxy)-nicotinic acid and (4-aminomethyl-3-fluoro-phenoxy)-acetic acid methyl ester materials, respectively.

WORKUP

后处理

customthat described in Preparation 20

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ad8f030e98d94f65a93a7007cec01ce5
来源数据集: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07183293B2
来源说明: uspto-grants-2007_02

反应 SMILES

[F:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[N:15]=[CH:14][CH:13]=[CH:12][C:8]=2[C:9]([OH:11])=O)=[CH:4][CH:3]=1.[C:18]([O:22][C:23](=[O:36])[CH:24]([O:26][C:27]1[CH:32]=[CH:31][C:30]([CH2:33][NH2:34])=[C:29]([F:35])[CH:28]=1)[CH3:25])([CH3:21])([CH3:20])[CH3:19].O1C2C=CC(OC3N=CC=CC=3C(O)=O)=CC=2OC1.COC(=O)COC1C=CC(CN)=C(F)C=1>>[C:18]([O:22][C:23](=[O:36])[CH:24]([O:26][C:27]1[CH:32]=[CH:31][C:30]([CH2:33][NH:34][C:9]([C:8]2[C:7]([O:6][C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:17][CH:16]=3)=[N:15][CH:14]=[CH:13][CH:12]=2)=[O:11])=[C:29]([F:35])[CH:28]=1)[CH3:25])([CH3:19])([CH3:20])[CH3:21]