反应详情

温度

0 °C

To a solution of phenyl disulfide (4.36 g, 20 mmol) in dichloromethane (40 mL) at 0° C. is added a solution of chlorosulfonic acid (4.64 g, 2.95 mL, 40 mmol) in dichloromethane (60 mL) dropwise. The mixture is stirred at 0° C. for 1 hour followed by 1.5 hours at room temperature. The reaction mixture is concentrated to dryness in vacuo and the residue is partitioned between diethyl ether and water. The water phase is separated, made basic with 2N aqueous sodium hydroxide and concentrated in vacuo to half the volume. The resulting solution is refrigerated overnight. The precipitate formed overnight is discarded, the filtrate is concentrated further in vacuo until a solid started to appear. The mixture is placed in the refrigerator for 2 hours. The mixture is treated with ethanol, the solid formed is filtered, washed with ethanol twice and dried under high vacuum overnight at room temperature to give 6.0 g of 4,4′-dithiobisbenzenesulfonic acid as a white solid: [M−1]−=398.8.

1. waitfollowed by 1.5 hours at room temperature
2. concentrationThe reaction mixture is concentrated to dryness in vacuo
3. customthe residue is partitioned between diethyl ether and water
4. customThe water phase is separated
5. concentrationconcentrated in vacuo to half the volume
6. waitThe resulting solution is refrigerated overnight
7. customThe precipitate formed overnight
8. concentrationthe filtrate is concentrated further in vacuo until a solid
9. waitThe mixture is placed in the refrigerator for 2 hours
10. additionThe mixture is treated with ethanol
11. customthe solid formed
12. filtrationis filtered
13. washwashed with ethanol twice
14. customdried under high vacuum overnight at room temperature