Sodium Hydroxide → HCID 67019595, compound

Participants

Reaction Steps

3-(2-phenylsulfamoyl-phenyl)-acrylic acid methyl ester (34a) (0.30 g, 0.94 mmol) was dissolved in methanol (4 ml), 1N NaOH solution (2.82 ml, 2.82 mmol) was added and the resultant solution was stirred at ambient temperature overnight The reaction mixture was partitioned between ethyl acetate and water. The aqueous layer was acidified with 10% HCl solution and stirred at ambient temperature for 1 hour. The precipitated solid was filtered, washed with water and dried in desiccator over P2O5. The title compound (0.2 g, 70%) was obtained as a white solid. 1H NMR (DMSO-d6, HMDSO), δ: 6.40 (1H, d, J=16.0 Hz); 6.93–7.32 (5H, m); 7.45–8.00 (5H, m); 8.47 (1H, d, J=16.0 Hz); 10.59 (1H, br s).

Provenance & Evidence