HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 178425645, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 3-Chloro-4-fluorobenzenesulphonyl chloride | HCID 145222 | — |
| Reactant | 3-Fluoro-4-methylbenzene-1-carboximidamide--hydrogen chloride (1/1) | HCID 16667439 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178425645 | HCID 178425645 | 36% |
Reaction Steps
Add 3-fluoro-4-methylbenzamidine hydrochloride (0.025 g, 0.133 mmol) in THF (0.5 mL) to 3-chloro-4-fluorophenyl sulfonylchloride (0.0304 g, 0.133 mmol) followed by N-methylmorpholine (0.2 mL). The reaction mixture was concentrated and chromatographed using reverse phase chromatography (gradient of 5–95% (0.1% TFA in CH3CN) in (0.1% TFA in H2O). A white solid (16.4 mg, 36%) was isolated. ES Positive Ion MS [M+H]+ ions observed: m/z 345 (35Cl) and m/z 347 (37Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07183320B2 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-44a9351510d64d7b92f38cfef0672da9 |
| Source note | uspto-grants-2007_02 |