2-Pyrazinecarboxylic acid → HCID 22256455, compound

Participants

Reaction Steps

To a stirred solution of N-(t-butyloxycarbonyl)-N-(2-pyridinylmethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine (183 mg, 0.40 mmol) in dry CH2Cl2 (5 mL) was added 2-pyrazinecarboxylic acid (68 mg, 0.55 mmol), N,N -diisopropylethylamine (0.21 mL, 1.21 mmol), 1-hydroxybenzotriazole hydrate (81 mg, 0.60 mmol) and 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide HCl (EDC) (115 mg, 0.60 mmol) and the mixture was stirred at room temperature for 20 hours. Following standard work-up procedures, the crude material was purified by column chromatography on silica gel (CH2Cl2/MeOH, 98:2 followed by 95:5) to give the desired amide (131 mg, 58%) as a colorless oil.

Provenance & Evidence