1,4-Dioxane hydrochloride → HCID 21090829, compound

HRID 351194Notes

Reaction equation

HRID 351194 reaction equation
[ClH:1].O1CCOCC1.[CH:8]([C:11]1[CH:15]=[C:14]([C:16]2[CH:32]=[CH:31][C:19]([O:20][CH2:21][CH2:22][NH:23]C(=O)OC(C)(C)C)=[CH:18][CH:17]=2)[N:13]([C:33]2[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=2)[N:12]=1)([CH3:10])[CH3:9]>ClCCl>[ClH:1].[CH:8]([C:11]1[CH:15]=[C:14]([C:16]2[CH:32]=[CH:31][C:19]([O:20][CH2:21][CH2:22][NH2:23])=[CH:18][CH:17]=2)[N:13]([C:33]2[CH:34]=[CH:35][C:36]([O:39][CH3:40])=[CH:37][CH:38]=2)[N:12]=1)([CH3:10])[CH3:9]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 21091171HCID 21091171, compound

Product 1

HCID 21090829HCID 21090829, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4M Hydrochloric acid/dioxane (2 ml) was added to a solution of tert-butyl 2-{4-[3-isopropyl-1-(4-methoxy-phenyl)-1H-pyrazol-5-yl]-phenoxy}ethylcarbamate obtained by Example 2 (382 mg) in dichloromethane (3 ml) at 0° C.

Sources & evidence

ORD record
ord-a272506150124857b7b9bc12f562aee4
Source dataset
uspto-grants-2007_02
Patent number
US07183306B2

Reaction notes

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