HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isoamyl Nitrite → 3-Chloro-5-[4-(methoxymethoxy)phenyl]-1-(4-methoxy-phenyl)-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isoamyl Nitrite | HCID 8053 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | 5-[4-(Methoxymethoxy)phenyl]-1-(4-methoxyphenyl)-1H-pyrazol-3-amine | HCID 21091003 | — |
| Catalyst | Cupric Chloride | HCID 24014 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-Chloro-5-[4-(methoxymethoxy)phenyl]-1-(4-methoxy-phenyl)-1H-pyrazole | HCID 21090861 | — |
Reaction Steps
A mixture of 5-[4-(methoxymethoxy)phenyl]-1-(4-methoxyphenyl)-1H-pyrazol-3-amine obtained by Example 20-2 (3.79 g), lithium chloride (2.47 g), and copper (II) chloride (3.13 g) in acetonitrile (60 ml) was stirred at room temperature for 10 min. To this mixture was added isoamyl nitrite (2.73 g), and the mixture was stirred at room temperature for 1 hr.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07183306B2 |
| Source dataset | uspto-grants-2007_02 |
| ORD ID | ord-609e667e53024d199962f464f539e5cc |
| Source note | uspto-grants-2007_02 |