Hydrazine → HCID 21090709, compound

HRID 351209Notes

Reaction equation

HRID 351209 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][N:21]4C(=O)C5C(=CC=CC=5)C4=O)=[CH:15][CH:14]=3)=[CH:11][C:10]([C:32]([F:35])([F:34])[F:33])=[N:9]2)=[CH:4][CH:3]=1.NN>C(#N)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][NH2:21])=[CH:15][CH:14]=3)=[CH:11][C:10]([C:32]([F:34])([F:33])[F:35])=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 21090701HCID 21090701, compound

Product 1

HCID 21090709HCID 21090709, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 2-(2-{4-[1-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenyl}ethyl)-1H-isoindole-1,3(2H)-dione obtained by Example 52 (1.5 g) and hydrazine (2.93 ml) in acetonitrile (30 ml) was stirred at 60° C. for 5 hrs.

Sources & evidence

ORD record
ord-8ef09d9ed5b6469380e1a9c680f1cd93
Source dataset
uspto-grants-2007_02
Patent number
US07183306B2

Reaction notes

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