Sodium Cyanate → HCID 21091139, compound

HRID 351216Notes

Reaction equation

HRID 351216 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:14]([C:15]3[CH:22]=[CH:21][C:18]([CH2:19][NH2:20])=[CH:17][CH:16]=3)[N:13]=[C:12]([C:23]([F:26])([F:25])[F:24])[CH:11]=2)=[CH:6][CH:5]=1.[O-:27][C:28]#[N:29].[Na+]>O.C(O)C>[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:14]([C:15]3[CH:22]=[CH:21][C:18]([CH2:19][NH:20][C:28]([NH2:29])=[O:27])=[CH:17][CH:16]=3)[N:13]=[C:12]([C:23]([F:26])([F:24])[F:25])[CH:11]=2)=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 517096Sodium CyanateHCID 21090957HCID 21090957, compound

Product 1

HCID 21091139HCID 21091139, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 4-[5-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylamine hydrochloride obtained by Example 70 (150 mg) in water (8 ml) and ethanol (4 ml) was added sodium cyanate (100 mg) under ice cooling.

Sources & evidence

ORD record
ord-8ca988dbcf72487f9b5222ad306a3834
Source dataset
uspto-grants-2007_02
Patent number
US07183306B2

Reaction notes

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