HCID 21091112, compound → HCID 21091035, compound

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Reaction Steps

To a solution of N-(2-{4-[l-[4-(benzyloxy)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxy}ethyl)urea obtained by Example 80 (10.33 g) in methanol (100 ml) was added palladium on carbon (10% wet, 2 g), and the mixture was stirred vigorously at room temperature under hydrogen atmosphere for 3 hrs. The whole mixture was filtered and evaporated to give oil (8.23 g). The oil was purified with silica gel column chromatography [250 ml, 3% methanol/chloroform (500 ml), 5% methanol/chloroform (500 ml), and 10% methanol/chloroform (500 ml)] to give the target compound (8.07 g, 95.4%) as an oil.

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