反应详情

To a solution of N′-[5-[4-(benzyloxy)phenyl]-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-N,N-dimethylurea (1.19 g) in EtOH (10 ml) and THF (10 ml) were added a solution of ammonium formate (509 mg) in H2O (2 ml) and 10% Pd-C 50% wet (150 mg). The mixture was refluxed for 1 hour. The catalyst was filtered off through a celite pad and the pad was washed with EtOH. The filtrate and combined washings were concentrated in vacuo. To the residue were added AcOEt and H2O. White precipitates were appeared and collected and washed with H2O and IPE successively to give N′-[5-(4-hydroxyphenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-N,N-dimethylurea (555 mg) as a white powder.

1. temperatureThe mixture was refluxed for 1 hour
2. filtrationThe catalyst was filtered off through a celite pad
3. washthe pad was washed with EtOH
4. concentrationwere concentrated in vacuo
5. additionTo the residue were added AcOEt and H2O
6. customWhite precipitates
7. customcollected
8. washwashed with H2O and IPE successively