Hydrochloric Acid → HCID 21091065, compound

Participants

Reaction Steps

A 4M solution of HCl in dioxane (3 ml) was added to a solution of tert-butyl [5-(4-{2-[(aminocarbonyl)amino]ethoxy}-phenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]carbamate (478 mg) in CH2Cl2 (3 ml) The reaction mixture was stirred at ambient temperature for 5 hours and concentrated in vacuo. The residue was partitioned between CDCl3 and saturated aqueous sodium bicarbonate solution. The aq layer was reextrated with CHCl3. The combined organic layer was dried over magnesium sulfate, and concentrated in vacuo. The residue was purified by silica gel column chromatography eluted with CHCl3:MeOH:28% aqueous NH4OH=10:1:0.1 to give N-(2-{4-[3-amino-1-(4-methoxyphenyl)-1H-pyrazol-5-yl]phenoxy}ethyl)urea (244.6 mg) as an amorphous powder.

Provenance & Evidence