HCID 21090883, compound → HCID 21090884, compound

Participants

Reaction Steps

To a solution of 4-[1-(6-methoxy-3-pyridinyl)-3-(2,2,2-trifluoroethoxy)-1-H-pyrazol-5-yl]benzonitrile (197 mg) in THF (2 ml) was added lithium aluminum hydride (30 mg) under ice-bath cooling. The mixture was stirred at same temperature for 1 hour and then at ambient temperature for 2 hours. The reaction was quenched by adding 5% aqueous solution of potassium sodium tartaric acid (ca. 0.5 ml) . The mixture was diluted with AcOEt, dried over MgSO4, and filtered through a celite pad. The filtrate was concentrated in vacuo to give {4-[1-(6-methoxy-3-pyridinyl)-3-(2,2,2-trifluoro-ethoxy)-1-H-pyrazol-5-yl]benzyl}amine (200 mg) as an oil.

Provenance & Evidence