HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3,4-Tetrahydroquinoline → 1-(4-Methyl-2-nitrophenyl)-1,2,3,4-tetrahydroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3,4-Tetrahydroquinoline | HCID 69460 | — |
| Reactant | 4-Fluoro-3-nitrotoluene | HCID 136287 | — |
| Reactant | 9-Flouro-6-(4-methyl-1-piperazinyl)-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepine | HCID 13823288 | — |
| Product | 1-(4-Methyl-2-nitrophenyl)-1,2,3,4-tetrahydroquinoline | HCID 21297653 | — |
| Product | 2-[3,4-Dihydro-1(2H)-quinolinyl]-5-methylaniline | HCID 21297677 | — |
Reaction Steps
Starting with 1,2,3,4-tetrahydroquinoline and 2-fluoro-5-methylnitrobenzene and following the steps of 1a to 1f of Example 2, one may obtain, in sequence, 1-(4-methyl-2-nitrophenyl)-1,2,3,4-tetrahydroquinoline, 1-(2-amino-4-methylphenyl)-1,2,3,4-tetrahydroquinoline, N-[2-{1-(5-methylphenyl)-1,2,3,4 -tetrahydroquinolin-1-yl}]-4-methyl-1-piperazine carboxamide, and 10-methyl-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino-[1,8-ab][15]benzodiazepine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04764616 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-ac0909971d8449eea6e0428c5ff3bae3 |
| Source note | uspto-grants-1988_08 |