Oxygen → gamma-t-Butyl-alpha-hydroxy-gamma-methyl-gamma-butyrolactone

Participants

Reaction Steps

A mixture of 3 mmol of methyl acrylate, 15 mmol of 3,3-dimethyl-2-butanol, 0.6 mmol of N-hydroxyphthalimide, 0.003 mmol of cobalt(II) acetate, 0.03 mmol of acetylacetonatocobalt(III), and 1 ml of acetonitrile was stirred at 60° C. in an oxygen atmosphere (1 atm) for 8 hours. A reaction mixture was subjected to column chromatography on a silica gel to yield γ-t-butyl-α-hydroxy-γ-methyl-γ-butyrolactone in a yield of 71%.

Provenance & Evidence