Oxygen → 3-Hydroxy-1-oxaspiro[4.5]decan-2-one

Participants

Reaction Steps

A mixture of 3 mmol of methyl acrylate, 15 mmol of 3,3-dimethyl-2-butanol, 0.3 mmol of N-hydroxyphthalimide, 0.003 mmol of cobalt(II) acetate, 0.03 mmol of acetylacetonatocobalt(III), and 1 ml of acetonitrile was stirred at 50° C. in an oxygen atmosphere (1 atm) for 5 hours. A reaction mixture was subjected to column chromatography on a silica gel to yield 3-hydroxy-2-oxo-1-oxaspiro[4.5]decane in a yield of 83%.

Provenance & Evidence