Oxygen → HCID 18436240, compound

Participants

Reaction Steps

A mixture of 3 mmol of methyl 3-cyano-acrylate, 30 mmol of 2-propanol, 0.6 mmol of N-hydroxyphthalimide, 0.003 mmol of cobalt(II) acetate, 0.03 mmol of acetylacetonatocobalt(III), and 1 ml of acetonitrile was stirred at 70° C. in an oxygen atmosphere (1 atm) for 8 hours. A reaction mixture was subjected to column chromatography on a silica gel to yield β-cyano-α-hydroxy-γ,γ-dimethyl-γ-butyrolactone in a yield of 68%.

Provenance & Evidence