Trifluoroacetic acid → HCID 86594361, compound

Participants

Reaction Steps

The product of procedure (28e), (±) 1-[(1S*,2R*,4R*)-4-isopropylamino-2-(4-methylsulfanyl-benzenesulfonylmethyl)-cyclohexyl]-4-(3-trifluoromethyl-phenyl)-5,6-dihydro-1H-pyridin-2-one (˜10 mg), was dissolved in MeOH. The resulting solution was charged with ˜20 mg 10% Pd/C, stirred under 1 atm of H2 for 12 h, filtered, and concentrated in vacuo. The residue was redissolved in MeOH. The resulting solution was charged with ˜40 mg 10% Pd/C, stirred under 55 atm of H2 for 12 h, filtered, and concentrated in vacuo. The residue was redissolved in MeOH. The resulting solution was charged with ˜50 mg 10% Pd/C, stirred under 55 atm of H2 for 36 h, filtered, and concentrated in vacuo. The residue was dissolved in 0.5% TFA/MeCN and concentrated in vacuo to afford a mixture of diastereomers as the title compound as its TFA salt (10 mg). MS found: (M+H)+=537.

Provenance & Evidence