Trimethylsilyldiazomethane → HCID 11196284, compound

Participants

Reaction Steps

To a solution of (S)-2-tert-butoxycarbonylamino-6-hydroxy-hexanoic acid (1 g, 6 mmol) in 30 mL of CH2Cl2 and 5 mL of MeOH at rt was slowly added TMSCHN2 (10 mL), and the reaction mixture was left with stirring for 1 h. The solvent was remove under reduced pressure, and the resulting residue was diluted with water and EtOAc. The organic layer was separated, dried over Na2SO4, and concentrated to afford an oil (S)-2-tert-butoxycarbonylamino-6-hydroxy-hexanoic acid methyl ester. MS [M+H]+ 262.

Provenance & Evidence