Formic Acid → HCID 178517998, compound

HRID 351404Notes

Reaction equation

HRID 351404 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[CH:15](O)=O>O>[F:14][C:11]([F:12])([F:13])[C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[N:1]=[CH:15][N:6]=[C:4]2[OH:5]

Participants

4

Reactant 2

HCID 284Formic AcidHCID 210882212-Amino-5-(trifluoromethyl)benzamide

Product 1

HCID 178517998HCID 178517998, compoundYield 49.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Amino-5-trifluoromethyl-benzamide (ButtPark) (1.00 g, 4.90 mmol, 1 eq.) and formic acid (3.30 mL, 87.2 mmol, 17.8 eq.) were refluxed for 2.5 hours. Cooled to rt then added water (10 mL). Stirred 15 minutes then filtered off solids which were present. The solids were dried at 110° C. for 3 hours to give 520 mg of white solids as product. LCMS detects (M+H)+=215.

Workup

  1. filtrationthen filtered off solids which
  2. customThe solids were dried at 110° C. for 3 hours

Sources & evidence

ORD record
ord-2fc870155b8b4535a7981dfce6dc7b42
Source dataset
uspto-grants-2007_02
Patent number
US07183270B2

Reaction notes

Loading…