HCID 21088274, compound → HCID 21088143, compound

HRID 351426Notes

Reaction equation

HRID 351426 reaction equation
[NH2:1][C@H:2]1[CH2:6][CH2:5][N:4]([C@H:7]2[CH2:12][CH2:11][C@@H:10]([N:13]([CH:15]([CH3:17])[CH3:16])[CH3:14])[CH2:9][C@H:8]2[CH2:18][S:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)(=[O:21])=[O:20])[C:3]1=[O:28].Cl[C:30]1[C:31]2[CH:43]=[C:42]([Cl:44])[CH:41]=[N:40][C:32]=2[N:33]=[C:34]([C:36]([F:39])([F:38])[F:37])[N:35]=1>>[C:22]1([S:19]([CH2:18][C@@H:8]2[CH2:9][C@H:10]([N:13]([CH:15]([CH3:16])[CH3:17])[CH3:14])[CH2:11][CH2:12][C@@H:7]2[N:4]2[CH2:5][CH2:6][C@H:2]([NH:1][C:30]3[C:31]4[CH:43]=[C:42]([Cl:44])[CH:41]=[N:40][C:32]=4[N:33]=[C:34]([C:36]([F:39])([F:37])[F:38])[N:35]=3)[C:3]2=[O:28])(=[O:21])=[O:20])[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 21088274HCID 21088274, compoundHCID 69034517HCID 69034517, compound

Product 1

HCID 21088143HCID 21088143, compound

Procedure

The titled compound was prepared from (3S)-3-amino-1-[(1S,2R,4R)-2-benzenesulfonylmethyl-4-(isopropyl-methyl-amino)-cyclohexyl]-pyrrolidin-2-one and 4,6-dichloro-2-trifluoromethyl-pyrido[2,3-d]pyrimidine using the conditions described in Example 106, part C. MS (ES+)=639 (M+H)+.

Sources & evidence

ORD record
ord-03cad63cda3a481aa959ffc0b9e4eb62
Source dataset
uspto-grants-2007_02
Patent number
US07183270B2

Reaction notes

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