HCID 69428865, compound → HCID 18436353, compound

Participants

Reaction Steps

To a solution of 2-(4-benzyloxy-phenyl)-3-ethyl-4-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-5-trimethylsilanyloxy methyl-cyclohexanol in DCM (1 mL) was added TiCl4 (0.033 mL, 3 eq.) and the mixture stirred until reaction was done. The reaction mixture was diluted with ethyl acetate (10 mL), and washed with 5% NaHCO3 aqueous solution, then brine. The crude products was purified on HPLC to yield 4-{6-ethyl-4-hydroxymethyl-5-methyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-cyclohex-1-enyl}-phenol.

Provenance & Evidence