1,4-Dioxane → HCID 69428901, compound

Participants

Reaction Conditions

Reaction Steps

Into a mixture of trifluoro-methanesulfonic acid 4-ethylperoxymethyl-5-methyl-6-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-cyclohexa-1,5-dienyl ester (118.5 mg, 0.2219 mmol), Pd (PPh3)4 (6.4 mg, 0.025 eq.) and K3PO4 (70.7 mg, 1.5 eq.) in 1,4-dioxane (5 mL) was bubbled N2 for 10 min. To the reaction mixture was then added 4-methoxy benzene boronic acid (37.1 mg, 0.2441 mmol). The resulting mixture was heated to 8° C. for 16 h, filtered through a plug of silica gel, concentrated and purified on preparative TLC (10% MeOH/DCM) to yield 4-(4-methoxy-phenyl)-6-methyl-5-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-cyclohex-3-enecarboxylic acid ethyl ester as light yellow oil.

Provenance & Evidence