HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 35146Generated: October 25, 2026
Potassium Carbonate → Diethyl-2-[4'-(4"-cyano-phenoxy)-phenoxy]-propionyl-malonate
https://huagongshe.com/reaction/35146
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Hydroxybenzonitrile | HCID 11907 | — |
| Reactant | Diethyl-2-(4'-fluoro-phenoxy)-propionyl-malonate | HCID 23037018 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Diethyl-2-[4'-(4"-cyano-phenoxy)-phenoxy]-propionyl-malonate | HCID 21295006 | 86% |
Reaction Steps
11.9 g of cyano-phenol and 32.6 g of diethyl-2-(4'-fluoro-phenoxy)-propionyl-malonate are dissolved in 150 ml of dimethyl sulfoxide, whereupon 13.8 g of potassium carbonate are added and the reaction mixture is stirred at 60° C. for 6 hours. The reaction mixture is filtered and the filtrate is evaporated. Thus 36 g of the desired compound are obtained, yield 86%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04765825 |
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| Source dataset | uspto-grants-1988_08 |
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| ORD ID | ord-39eba38794a340b28f97b842753e7fc2 |
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| Source note | uspto-grants-1988_08 |
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