Water → Monensin

HRID 351482Notes

Reaction equation

HRID 351482 reaction equation
[CH3:1][CH2:2][C@:3]1([C@H:31]2[O:35][C@H:34]([C@H:36]3[O:41][C@@:40]([OH:44])([CH2:42][OH:43])[C@H:39]([CH3:45])[CH2:38][C@@H:37]3[CH3:46])[CH2:33][C@H:32]2[CH3:47])[O:7][C@@H:6]([C@:8]2([CH3:30])[O:12][C@:11]3([O:17][C@H:16]([C@@H:18]([C@H:20]([O:26][CH3:27])[C@H:21]([C:23]([O-:25])=[O:24])[CH3:22])[CH3:19])[C@H:15]([CH3:28])[C@@H:14]([OH:29])[CH2:13]3)[CH2:10][CH2:9]2)[CH2:5][CH2:4]1.[Na+].O>C(O)C>[CH3:1][CH2:2][C@:3]1([C@@H:31]2[O:35][C@@H:34]([C@H:36]3[O:41][C@@:40]([OH:44])([CH2:42][OH:43])[C@H:39]([CH3:45])[CH2:38][C@@H:37]3[CH3:46])[CH2:33][C@@H:32]2[CH3:47])[O:7][C@@H:6]([C@@:8]2([CH3:30])[O:12][C@:11]3([O:17][C@H:16]([C@H:18]([C@@H:20]([O:26][CH3:27])[C@@H:21]([C:23]([OH:25])=[O:24])[CH3:22])[CH3:19])[C@H:15]([CH3:28])[C@@H:14]([OH:29])[CH2:13]3)[CH2:10][CH2:9]2)[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 962WaterHCID 2369092722373-78-03×

Product 1

HCID 441145MonensinYield 48%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Treatments were: 1) C; 2) HS; 3) HS plus 10 ppm AQ; 4) HS plus 5 ppm RUMENSIN® (Elanco, Greenfield, Ind.) and 5) HS plus 10 ppm AQ. Fermentations supplemented with RUMENSIN® were prepared by first dissolving the RUMENSIN® in 96% ethanol and then adding the same volume of deionized water, yielding a concentration of monensin (in 48% ethanol) that would result in 5 ppm in the rumen fluid-buffer mix when 0.25 ml of the solution was added to 29.5 ml of the rumen fluid-buffer solution; finally, 0.25 ml of deionized water was added to yield a final volume of 30 ml. Each of the other treatment conditions (including the control fermentations) were modified by adding the same amount of ethanol to each as was present in the RUMENSIN® fermentation. This was done by doubling the concentration of the stock solutions, adding 0.25 ml of the stock solution (or deionized water for the controls) and 0.25 ml of 46% ethanol.

Workup

  1. customwere prepared

Sources & evidence

ORD record
ord-2fe9681fa1ba4bfc9cfb500a8436e51f
Source dataset
uspto-grants-2004_06
Patent number
US06743440B1

Reaction notes

Loading…