3-[4-(Benzyloxy)phenyl]-2-ethoxypropanoic acid → 2-Ethoxyethyl (2RS) 3-[4-(benzyloxy)phenyl]-2-ethoxypropanoate

HRID 351494Notes

Reaction equation

HRID 351494 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([O:20][CH2:21][CH3:22])[C:17]([OH:19])=[O:18])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(OCCO)C>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH:16]([O:20][CH2:21][CH3:22])[C:17]([O:19][CH2:2][CH2:1][O:8][CH2:9][CH3:10])=[O:18])=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 109245703-[4-(Benzyloxy)phenyl]-2-ethoxypropanoic acid

Product 1

HCID 865870522-Ethoxyethyl (2RS) 3-[4-(benzyloxy)phenyl]-2-ethoxypropanoate

Reagents, catalysts & solvents 1

HCID 8076Glycol monoethyl etherSolvent

Procedure

The ester can be prepared by acid catalysed esterification of 3-[4-(benzyloxy)phenyl]-2-ethoxypropanoic acid with/in 2-ethoxyethanol. Isocratic HPLC method 2 (4.34 min.): 97.6%.

Workup

  1. customIsocratic HPLC method 2 (4.34 min.)

Sources & evidence

ORD record
ord-e13fe14f5dbb41cdbb3352709845ef24
Source dataset
uspto-grants-2004_06
Patent number
US06743608B2

Reaction notes

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