Acetate → HCID 86587062, compound

HRID 351501Notes

Reaction equation

[CH2:1]([O:3][CH:4]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1)[C:5]([O:7][CH:8]([CH3:10])[CH3:9])=[O:6])[CH3:2].P([O-])([O-])([O-])=O.C([O-])(=O)C>>[CH2:1]([O:3][C@@H:4]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([OH:18])=[CH:16][CH:17]=1)[C:5]([OH:7])=[O:6])[CH3:2].[CH2:1]([O:3][C@H:4]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1)[C:5]([O:7][CH:8]([CH3:10])[CH3:9])=[O:6])[CH3:2]

Participants

Reactant 3

HCID 175Acetate

HCID 1061Phosphate

HCID 68679680HCID 68679680, compound

Product 1

HCID 86587062HCID 86587062, compound

Procedure

Isopropyl (2RS) (+/−) 2-ethoxy-3-(4-hydroxyphenyl)propanoate (0.5 ml of a solution containing 2 mg/ml in a phosphate, pH 7; 0.1 M, or acetate buffer, pH 5; 0.1 M) was added to the reaction vessel followed by an enzyme (0.5 ml enzyme solution). The reaction mixture was shaken at room temperature and analysed at different times (maximum 28 h). The reaction mixture was analysed without work up by the gradient HPLC method 1, chiral HPLC methods 3 and 5, and by the CCE method 1.

Workup

addition0.1 M) was added to the reaction vessel
customanalysed at different times (maximum 28 h)

Sources & evidence

ORD record: ord-9b6842b77fcc4d7d9b5d72412f701d41
Source dataset: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06743608B2

Reaction notes

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